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Print - ISSN 2229 –7499

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July,2012  Volume3  Issue2

PREPARATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF CITALOPRAM HYDROBROMIDE

B. Rubia Yasmeen, S. Firoz, Y. Chandra Mouli, A. Vikram, B. Mahitha, U. Aruna

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 Sree Vidyanikethan College of Pharmacy, A.Rangampet, Tirupati, 517102, Andhra Pradesh, India.
 Author Email Id : rubia.pharma@gmail.com

 ABSTRACT Fast dissolving film is a dosage form which when placed in the oral cavity, quickly gets hydrated, sticks onto the site of application and then disintegrates to release the drug. Citalopram is an antidepressant also used for mood disorders such as anxiety and obsessive compulsive disorder. Fast dissolving films of Citalopram hydrobromide were prepared by solvent casting technique. HPMC E5 was selected as polymer because of its good water solubility. Propylene glycol as plasticizer and sorbitol as sweetener were used in the formulation. The compatibility of the drug in the formulation was confirmed by FTIR studies. Surfactants by their wetting ability further reduce the disintegration time and enhance the drug release in mouth dissolving films, so tween80 at concentrations of 10%w/w of polymer concentration was included in some formulations. By varying the concentration of polymer and surfactant, four formulations F1, F2, F3 and F4 were formulated. The prepared films were evaluated for their physico-chemical parameters like folding endurance, weight variation, thickness, surface pH, dissolving time and disintegration time. Estimation of drug content of films was performed and the results were satisfactory. Invitro dissolution studies revealed higher drug release from formulations F3 and F4. The order of drug release was found to be F3 > F4>F1>F2. Key words: Fast dissolving film, Citalopram hydrobromide, Tween80, Antidepressant.

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