e - ISSN 0976-1047
Print - ISSN 2229 Ė7499

Content on this page requires a newer version of Adobe Flash Player.

Get Adobe Flash player

For Authors

July,2012  Volume3  Issue2


B. Rubia Yasmeen, S. Firoz, Y. Chandra Mouli, A. Vikram, B. Mahitha, U. Aruna

 Sree Vidyanikethan College of Pharmacy, A.Rangampet, Tirupati, 517102, Andhra Pradesh, India.
 Author Email Id :

 ABSTRACT Fast dissolving film is a dosage form which when placed in the oral cavity, quickly gets hydrated, sticks onto the site of application and then disintegrates to release the drug. Citalopram is an antidepressant also used for mood disorders such as anxiety and obsessive compulsive disorder. Fast dissolving films of Citalopram hydrobromide were prepared by solvent casting technique. HPMC E5 was selected as polymer because of its good water solubility. Propylene glycol as plasticizer and sorbitol as sweetener were used in the formulation. The compatibility of the drug in the formulation was confirmed by FTIR studies. Surfactants by their wetting ability further reduce the disintegration time and enhance the drug release in mouth dissolving films, so tween80 at concentrations of 10%w/w of polymer concentration was included in some formulations. By varying the concentration of polymer and surfactant, four formulations F1, F2, F3 and F4 were formulated. The prepared films were evaluated for their physico-chemical parameters like folding endurance, weight variation, thickness, surface pH, dissolving time and disintegration time. Estimation of drug content of films was performed and the results were satisfactory. Invitro dissolution studies revealed higher drug release from formulations F3 and F4. The order of drug release was found to be F3 > F4>F1>F2. Key words: Fast dissolving film, Citalopram hydrobromide, Tween80, Antidepressant.

Jounrnal Search
Quick Links
Most Read Article
Pharma intelligence journals
  • Int J of Phytopharmacology
  • Int J of Biopharmaceutics
  • Int J of Pharmacy & Therapeutics
  • Int J of Biological & Pharmaceutical Research
  • Int J of Phytopharmacy Research
  • Int J of Preclinical and Pharm Research
  • Asian journal of Pharmaceutical Research
  • Journal of Science
  • Int J of Pharm Development and Technology
  • Asian J of Pharm Science and Technology
  • Int J of Current Pharm & Clinical Research
  • Int J of Experimental Pharmacology
  • Int J of Pharmaceutical Research and Analysis
  • Int J of Pharmacy Review and Research
  • Ind J of Pharmaceutical Science & Research
  • Journal of Pharmaceutical Biology
  • Int J of Medicinal Chemistry and Analysish
  • Int J of Innovative Drug Discovery
  • Int J of Pharmacy Practice and Drug Research
  • Int J of Pharmacology Research
  • Int J of Pharmacology and Toxicology
  • Int J of Pharmacy
  • Int J of Advanced Pharmaceutics
  • Int J of Phytotherapy
  • Int J of Pharmacological Screening Methods
  • Int J of Pharmacotherapy
    Copyright © 2010. All rights reserved.